EVALUATION Chennai, India. Mrs.Gayatri Devi.R Assistant Professor,

EVALUATION OF LIPID PROFILE STATUS IN METABOLIC SYNDROME (MetS)

Type of manuscript: Research article.
Running title: Lipid profile status in metabolic syndrome.

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A.Shamaa Anjum
Graduate Student,
Saveetha Dental College,
Saveetha University,
Chennai, India.

Mrs.Gayatri Devi.R
Assistant Professor, 
Department of physiology,
Saveetha Dental College,
Saveetha University,
Chennai, India.

Corresponding author
Mrs.Gayatri Devi.R
Assistant Professor, 
Department of physiology,
Saveetha Dental College, 
Saveetha University,
162, Poonamallee High Road
Chennai 600077
Tamil Nadu, India
Email: [email protected]
Telephone number: +918248016505
Total number of words: 1424

Abstract 
Introduction: Metabolic syndrome (MetS) is known as a group of cardiovascular risk factors associated with insulin resistance, hypertension, glucose intolerance, hypertriglyceridemia and low levels of high-density lipoprotein cholesterol (HDL-C). It is a major worldwide public health problem.The aim of this study is to analyse the lipid profile status in metabolic syndrome.
Materials and methods: Healthy individuals and individuals with metabolic syndrome underwent serum analysed for fasting blood sugar (FBS) by GOD-POD method, serum cholesterol by Cholesterol esterase-Oxidase method, Serum triglycerides by colorimetric enzymatic method, HDL-c by Phosphotungtic acid method, LDL-c and VLDL-c were calculated by Friedwald’s formula and lipid profile status was compared between the two groups.
Results: All the data were analysed by using SPSS package. The mean value of FBS, TGL, T.Chols, HDL-c, LDL-c and VLDL-c in individuals with metabolic syndrome was found to be 10531.22, 151.138.80, 191.15 35.12, 20.76.31, 140.335.37, 30.426.76 respectively.
Conclusion: From this study, it is evident that individuals with MetS have most of the risk factors that increases the person’s risk of heart attack and stroke. Aside from the increase in waist circumference, most of the disorders associated with MetS have no symptoms.

Key Words : Metabolic syndrome, lipid profile, heart diseases, obesity, diabetes.

Introduction: Metabolic syndrome (MetS) is known as a group of cardiovascular risk factors associated with insulin resistance, hypertension, glucose intolerance, hypertriglyceridemia and low levels of high-density lipoprotein cholesterol (HDL-C). It is a major worldwide public health problem 1. MetS is considered a major threat for public health in the 21st century 5 and is associated with an increased risk of cardiovascular disease (CVD) and pathophysiologic states such as heart failure 2, type 2 diabetes mellitus 3, and erectile dysfunction (ED) 4. Dyslipidemia is a risk factor for CVD and is a component of MetS; the role of HDL-C, triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) have already been established as  predictors of CVD17. Serum adiponectin secreted by the adipose tissue, contains four differentiable domains which regulate the lipid metabolism, glucose metabolism and insulin sensitivity 19.  Low circulating levels of serum adiponectin has been reported as a risk factor for the development of metabolic syndrome 20 and CVD 21 .In 1989, Kaplan 13 renamed MetS as “The Deadly Quartet” for the combination of upper body obesity, glucose intolerance, hypertriglyceridemia, and hypertension ; however, in 1992, it was again renamed as “The Insulin Resistance Syndrome” 14.

The prevalence of MetS increases with increase in glucose intolerance 6 and with the increasing world-wide prevalence of diabetes mellitus (DM). The prevalence of MetS in Chennai was found to be 46.316 . The expected increase in the frequency of occurrence of the MetS will be in geometric proportions.The prevalence of MetS in the general population is estimated to be between 17-25% 7,8 and in people with DM prevalence rates range from 59% to 61% 9.

The  metabolic  syndrome  study,  however,  has  not  been adequately  explored  in  the  60-year  old population or people above 60 years of age. The  understanding  of  the  extension  of  these kind of disorder  in  this population segment is  necessary for the national distribution of  resources  for  medical  care  and  research,  as  well  as  for the  adequate  management.  It  is  also  emphasized  that  the prevalence  of  MetS  in  elderly  people  has  not  been  defined; partly  because  they  have  been  traditionally  under – represented in large epidemiologic studies 10,11. Therefore in this study we aimed to analyse the lipid profile status in metabolic syndrome.

Materials and methods: Patients were selected from the outpatient department of Saveetha Dental College, and hospitals and divided into two groups. Each group consists of 25 individuals.
Group I: Normal healthy individuals  
Group II: Patients with metabolic syndrome
Inclusion Criteria
• Individuals with the age group of 35 to 55 years
• Individuals with type 2 diabetes mellitus (FBS ?100mg/dl)
• Individual with normal BMI (18.9 – 24.9) and Obese BMI (?30)
• Serum Triglycerides levels more than 150mg/dl
Exclusion Criteria
• Individuals with other systemic illness like cardio vascular disease, Renal failure, Stroke, endocrine illness.
• Individuals with acute illness like fever.
• Immunocompromised individuals.
Sample collection
            Informed consents were obtained from the patients before sample collection. 5ml of venous blood was collected and distributed in plain collection tubes and centrifuged in 3000rpm for serum. Then serum was separated and then it is analysed for fasting blood sugar (FBS) by GOD-POD method, serum cholesterol by Cholesterol esterase-Oxidase method, Serum triglycerides by colorimetric enzymatic method, HDL-c by Phosphotungtic acid method, LDL-c and VLDL-c were calculated by Friedwald’s formula.

Results: All the data were analysed by using SPSS package. Student t-test analysis was done to find out significant differences between the two groups. All the tests were considered significant at p